Colon A J, Ronner H E, Boon P, Ossenblok P
Department of Clinical Neurophysiology, ACE, location Kempenhaeghe, Heeze, The Netherlands.
Department of R&D, ACE, Heeze, The Netherlands.
Acta Neurol Scand. 2017 Feb;135(2):247-251. doi: 10.1111/ane.12586. Epub 2016 Mar 8.
MEG and EEG after sleep deprivation (EEG-SD) are applied as diagnostic tools in the evaluation of patients with possible epilepsy. There is no gold standard to check whether the diagnosis based on these two modalities is correct. The best standard available is the long-term follow-up of patients. As follow-up of an earlier study in which the additional value of MEG vs EEG-SD diagnosis was evaluated, we investigated the long-term validity of MEG-based and EEG-SD-based diagnosis.
Data collected from 46 patients were used in a comparative study of the last known diagnosis against the original one of 8 years ago.
Long-term (3-8 years) sensitivity of sharp phenomena (combining spikes and sharp waves) in routine MEG and in EEG-SD for the diagnosis epilepsy is 71% and 62%, respectively. When compared to the original study, this hardly changed. Over time, uncertainty on diagnosis diminishes.
MEG as well as EEG-SD are robust long-term predictors for epilepsy.
睡眠剥夺后的脑磁图（MEG）和脑电图（EEG-SD）被用作评估疑似癫痫患者的诊断工具。目前尚无金标准来检验基于这两种方法的诊断是否正确。现有的最佳标准是对患者进行长期随访。作为对一项早期研究的后续跟进，该研究评估了MEG与EEG-SD诊断的附加价值，我们调查了基于MEG和基于EEG-SD诊断的长期有效性。
从46例患者收集的数据用于一项对照研究，将最后已知诊断结果与8年前的原始诊断结果进行对比。
常规MEG和EEG-SD中尖锐现象（结合棘波和尖波）对癫痫诊断的长期（3 - 8年）敏感性分别为71%和62%。与原始研究相比，这一结果几乎没有变化。随着时间推移，诊断的不确定性降低。
MEG以及EEG-SD都是癫痫可靠的长期预测指标。
