与骨闪烁显像相比，F-18 氟化钠正电子发射断层扫描/计算机断层扫描用于检测甲状腺癌骨转移
F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy.
作者信息
Lee Hyunjong, Lee Won Woo, Park So Yeon, Kim Sang Eun
机构信息
Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul 13620, Korea.; World Class University, Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea.
Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul 13620, Korea.; Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 03087, Korea.
出版信息
Korean J Radiol. 2016 Mar-Apr;17(2):281-8. doi: 10.3348/kjr.2016.17.2.281. Epub 2016 Mar 2.
OBJECTIVE
The aim of the study was to compare the diagnostic performances of F-18 sodium fluoride positron emission tomography/computed tomography (bone PET/CT) and bone scintigraphy (BS) for the detection of thyroid cancer bone metastasis.
MATERIALS AND METHODS
We retrospectively enrolled 6 thyroid cancer patients (age = 44.7 ± 9.8 years, M:F = 1:5, papillary:follicular = 2:4) with suspected bone metastatic lesions in the whole body iodine scintigraphy or BS, who subsequently underwent bone PET/CT. Pathologic diagnosis was conducted for 4 lesions of 4 patients.
RESULTS
Of the 17 suspected bone lesions, 10 were metastatic and 7 benign. Compared to BS, bone PET/CT exhibited superior sensitivity (10/10 = 100% vs. 2/10 = 20%, p = 0.008), and accuracy (14/17 = 82.4% vs. 7/17 = 41.2%, p < 0.025). The specificity (4/7 = 57.1%) of bone PET/CT was not significantly different from that of BS (5/7 = 71.4%, p > 0.05).
CONCLUSION
Bone PET/CT may be more sensitive and accurate than BS for the detection of thyroid cancer bone metastasis.
目的
本研究旨在比较F-18氟化钠正电子发射断层扫描/计算机断层扫描（骨PET/CT）和骨闪烁显像（BS）对甲状腺癌骨转移的诊断效能。
材料与方法
我们回顾性纳入了6例甲状腺癌患者（年龄=44.7±9.8岁，男:女=1:5，乳头状癌:滤泡状癌=2:4），这些患者在全身碘闪烁显像或BS检查中怀疑有骨转移灶，随后接受了骨PET/CT检查。对4例患者的4个病灶进行了病理诊断。
结果
17个疑似骨病灶中，10个为转移灶，7个为良性。与BS相比，骨PET/CT表现出更高的敏感性（10/10 = 100%对2/10 = 20%，p = 0.008）和准确性（14/17 = 82.4%对7/17 = 41.2%，p < 0.025）。骨PET/CT的特异性（4/7 = 57.1%）与BS的特异性（5/7 = 71.4%）无显著差异（p > 0.05）。
结论
在检测甲状腺癌骨转移方面，骨PET/CT可能比BS更敏感、更准确。
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