Betta A, Maranelli G, Dal Ri C
Med Lav. 1989 Sep-Oct;80(5):381-9.
Pesticides have been reported as altering immune functions in animals and man. The authors review published data from which it emerges that pesticide exposure is often associated with depressed humoral and cellular responses in mammals. The immunomodulating effects are affected by the route of administration and can also occur without general toxic effects, with a clear dose-effect correlation and for different dose levels. Immunotoxicity has also been investigated in workers occupationally exposed to pesticides: many kinds of effects are described, since many immunotoxicants have multiple effects on immune functions but the authors emphasize the importance of further studies carried out in workplace situations where exposure levels can be more accurately measured.
据报道，农药会改变动物和人类的免疫功能。作者回顾了已发表的数据，从中发现接触农药通常与哺乳动物体液和细胞反应受抑制有关。免疫调节作用受给药途径影响，也可能在无一般毒性作用的情况下发生，存在明显的剂量效应关系，且针对不同剂量水平。还对职业接触农药的工人进行了免疫毒性研究：描述了多种效应，因为许多免疫毒物对免疫功能有多种影响，但作者强调在能更准确测量接触水平的工作场所进行进一步研究的重要性。
