Arrayhani Mohamed, Sqalli Tarik, Tazi Nada, El Youbi Randa, Chaouch Safae, Aqodad Nourdin, Ibrahimi Sidi Adil
Nephrology Department, University Hospital Hassan II, Fez, Morocco.
Faculty of Medicine and Pharmacy, Fez, Morocco.
Pan Afr Med J. 2015 Nov 23;22:273. doi: 10.11604/pamj.2015.22.273.2311. eCollection 2015.
The liver biopsy has long been the "gold standard" for assessing liver fibrosis in patients with hepatitis C. It's an invasive procedure which is associated with an elevated bleeding, especially in chronic hemodialysis patients. Main goal is to assess liver fibrosis in chronic hemodialysis with HCV by Fibroscan and by biological scores (APRI, Forns and Fib-4), and to measure the correlation between these tests. Cross-sectional study including all chronic hemodialysis patients with hepatitis C virus, in two public hemodialysis centers of Fez. All patients were evaluated for liver fibrosis using noninvasive methods (FibroScan and laboratory tests). Subsequently, the correlation between different tests has been measured. 95 chronic hemodialysis were studied, twenty nine patients (30.5%) with chronic hepatitis C. The average age was 52.38 ± 16.8 years. Nine liver fibrosis cases have been concluded by forns score. Fibroscan has objectified significant fibrosis in 6 cases. On the other side APRI has objectified sgnifivant fibrosis only in 3 cases. The Fib-4 showed severe fibrosis in five cases. The results have been most consistent between APRI and Fib-4, followed by Fibroscan and Forns, then APRI and FibroScan.
长期以来，肝活检一直是评估丙型肝炎患者肝纤维化的“金标准”。这是一种侵入性检查，有出血风险增加的情况，尤其是在慢性血液透析患者中。主要目的是通过Fibroscan和生物学评分（APRI、Forns和Fib-4）评估慢性血液透析合并丙型肝炎患者的肝纤维化情况，并测量这些检查之间的相关性。在非斯的两个公共血液透析中心开展了一项横断面研究，纳入所有慢性丙型肝炎病毒感染的血液透析患者。所有患者均使用非侵入性方法（FibroScan和实验室检查）评估肝纤维化情况。随后，测量了不同检查之间的相关性。共研究了95例慢性血液透析患者，其中29例（30.5%）患有慢性丙型肝炎。平均年龄为52.38±16.8岁。Forns评分诊断出9例肝纤维化病例。Fibroscan检测出6例有明显纤维化。另一方面，APRI仅检测出3例有明显纤维化。Fib-4检测出5例有严重纤维化。结果显示，APRI和Fib-4之间的一致性最高，其次是Fibroscan和Forns，然后是APRI和FibroScan。
