Sochat Vanessa, David Maude, Wall Dennis P
Stanford Graduate Fellow, Graduate Program in Biomedical Informatics.
Department of Pediatrics, Systems Medicine Division Stanford University School of Medicine Stanford, CA 94305.
AMIA Annu Symp Proc. 2015 Nov 5;2015:2073-82. eCollection 2015.
The task of mapping neurological disorders in the human brain must be informed by multiple measurements of an individual's phenotype - neuroimaging, genomics, and behavior. We developed a novel meta-analytical approach to integrate disparate resources and generated transcriptional maps of neurological disorders in the human brain yielding a purely computational procedure to pinpoint the brain location of transcribed genes likely to be involved in either onset or maintenance of the neurological condition.
绘制人类大脑神经疾病图谱的任务必须依据对个体表型的多种测量——神经影像学、基因组学和行为学。我们开发了一种新颖的元分析方法，以整合不同的资源，并生成人类大脑神经疾病的转录图谱，从而产生一种纯粹的计算程序，以确定可能参与神经疾病发病或维持过程的转录基因在大脑中的位置。
