Ghasemian Roya, Shokri Mehran, Makhlough Atieh, Suraki-Azad Mohammad Amin
Antimicrobial Resistance Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Science, Babol, Iran.
Caspian J Intern Med. 2016 Winter;7(1):7-12.
Renal complication of leptospirosis is common and its clinical manifestations vary from urinary sediment changes to acute renal failure. The aim of this study was to determine the final outcome of renal involvement in leptospirosis.
This longitudinal prospective study included all serologically confirmed cases of leptospirosis with evidence of renal failure. All patients were followed for three months while all patients with renal failure were followed-up for one year.
Fifty-one patients, 53.5±14.8 years (82.4% males) with acute renal failure were studied. Over the hospitalization period, 28 patients recovered, and seven (13.72%) patients died of multiple organ failure. At the time of discharge, 16 patients had mild renal failure. Over the follow-up period, all patients recovered but in two patients renal failure persisted at creatinine level of 1.5 mg/dl.
Development of renal failure in leptospirosis is not rare. Recovery of renal function may last several months. However, most patients recover completely at least after one year.
钩端螺旋体病的肾脏并发症很常见，其临床表现从尿沉渣改变到急性肾衰竭不等。本研究的目的是确定钩端螺旋体病肾脏受累的最终结局。
这项纵向前瞻性研究纳入了所有血清学确诊且有肾衰竭证据的钩端螺旋体病病例。所有患者随访三个月，而所有肾衰竭患者随访一年。
研究了51例急性肾衰竭患者，年龄为53.5±14.8岁（82.⁴%为男性）。在住院期间，28例患者康复，7例（13.72%）患者死于多器官功能衰竭。出院时，16例患者有轻度肾衰竭。在随访期间，所有患者均康复，但有2例患者的肾衰竭持续存在，肌酐水平为1.5mg/dl。
钩端螺旋体病并发肾衰竭并不罕见。肾功能的恢复可能持续数月。然而，大多数患者至少在一年后可完全康复。
