沙柏康唑（R 66905）对念珠菌和球拟酵母菌的体外抗真菌活性。

In vitro antifungal activity of saperconazole (R 66905) against Candida and Torulopsis.

作者信息

Mallié M, Montès B, Lebecq J C, Bastide J M

出版信息

Mycoses. 1989 Dec;32(12):631-7. doi: 10.1111/j.1439-0507.1989.tb02195.x.

DOI:10.1111/j.1439-0507.1989.tb02195.x

Abstract

The susceptibility of several strains of Candida and Torulopsis to saperconazole, a new triazole antifungal compound, was compared to that of ketoconazole. The MICs of the two antifungal agents were determined against 70 strains of Candida albicans, 10 strains of C. guilliermondii, 10 strains of C. krusei, 10 strains of C. parapsilosis, 10 strains of C. pseudotropicalis, 10 strains of C. tropicalis and 15 strains of Torulopsis glabrata. The fungistatic activity was evaluated by the agar dilution method using BHI and casitone media after incubation for 48 hours at 28-30 degrees C. The in vitro activity of saperconazole was similar to that of ketoconazole for most of the Candida spp. tested except for C. krusei in particular. An MIC of less than or equal to 3.12 micrograms/ml for saperconazole was found with 92% of the C. albicans strains tested. In contrast, T. glabrata was more susceptible to ketoconazole.

摘要

将几种念珠菌和球拟酵母菌菌株对新型三唑类抗真菌化合物沙康唑的敏感性与酮康唑进行了比较。测定了这两种抗真菌剂对70株白色念珠菌、10株季也蒙念珠菌、10株克鲁斯念珠菌、10株近平滑念珠菌、10株伪热带念珠菌、10株热带念珠菌和15株光滑球拟酵母菌的最低抑菌浓度（MIC）。采用琼脂稀释法，在BHI和酪蛋白胨培养基中于28 - 30℃孵育48小时后评估抑菌活性。除了克鲁斯念珠菌外，对于大多数测试的念珠菌属，沙康唑的体外活性与酮康唑相似。在所测试的白色念珠菌菌株中，92%的菌株对沙康唑的MIC小于或等于3.12微克/毫升。相比之下，光滑球拟酵母菌对酮康唑更敏感。