Wołoszczuk-Gebicka Bogumiła
Dev Period Med. 2015 Jul-Sep;19(3 Pt 1):319-23.
Approximately 1.5 million neonates receive general anaesthesia each year for surgical procedures. Providing anaesthesia to neonates is not easy. Surgical procedures are often difficult and extensive, and the physiology of neonates makes respiratory and cardiovascular problems more frequent and life-threatening. The paper covers the changing concepts in neonatal anaesthesia, including recent studies that indicate that anaesthetic exposure could cause neuronal apoptosis in the developing brain. This could potentially influence the long-term developmental outcome, especially in infants requiring multiple surgical procedures. Respiratory and cardiovascular critical events, age-related differences of the pharmacokinetics of the drugs used for anaesthesia, as well as technical problems are also covered.
每年约有150万新生儿因外科手术接受全身麻醉。为新生儿提供麻醉并非易事。外科手术往往难度大且范围广，新生儿的生理状况使呼吸和心血管问题更频繁且危及生命。本文涵盖了新生儿麻醉中不断变化的概念，包括近期研究表明麻醉暴露可能导致发育中的大脑发生神经元凋亡。这可能会潜在地影响长期发育结果，尤其是对于需要多次外科手术的婴儿。文中还涉及呼吸和心血管危急事件、麻醉所用药物药代动力学的年龄相关差异以及技术问题。
