遗传风险评分在年龄相关性黄斑变性中的应用：综述
The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review.
作者信息
Cooke Bailey Jessica N, Hoffman Joshua D, Sardell Rebecca J, Scott William K, Pericak-Vance Margaret A, Haines Jonathan L
机构信息
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA.
出版信息
J Clin Med. 2016 Mar 4;5(3):31. doi: 10.3390/jcm5030031.
Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD.
年龄相关性黄斑变性（AMD）是一种高度流行且对衰老有重大影响的疾病，无疑受到遗传和环境因素之间复杂相互作用的影响。已经测试了各种风险评分，以评估可测量的遗传和环境因素对疾病的影响。我们在此总结并回顾了这些众多模型预测AMD的能力和效用，并提出了其他风险因素，以便纳入临床上有用的AMD预测模型中。
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