Abdurakhmanova A M, Rakhimov N R, Kosovskiĭ M I
Probl Endokrinol (Mosk). 1989 Nov-Dec;35(6):20-3.
Altogether 155 patients with different clinical types of liver lesions were examined: 73 with chronic persistent hepatitis (CPH), 39 with chronic active hepatitis (CAH), and 43 with liver cirrhosis (LC). The patients with chronic liver diseases demonstrated hyperinsulinemia and a decrease in glucose tolerance, a frequency and degree of this decrease growing with the severity of a pathological process. It is postulated taking experiments with partial hepatectomy of rats by way of example that intolerance to glucose and hyperinsulinemia is caused by partial loss of glycogen synthetic function by the liver resulting from a decrease in the number of functionally active cell elements. Experience with 8 LC patients with secondary diabetes mellitus has shown that the addition of the latter is connected with the reduction of secretory capacity of pancreatic beta-cells and with the development of relative insulin insufficiency.
共检查了155例不同临床类型肝脏病变患者：73例慢性持续性肝炎（CPH），39例慢性活动性肝炎（CAH），43例肝硬化（LC）。慢性肝病患者表现为高胰岛素血症和糖耐量降低，这种降低的频率和程度随病理过程的严重程度而增加。以大鼠部分肝切除术实验为例推测，葡萄糖不耐受和高胰岛素血症是由于功能活跃细胞成分数量减少导致肝脏糖原合成功能部分丧失所致。对8例继发性糖尿病肝硬化患者的研究表明，后者的发生与胰岛β细胞分泌能力降低及相对胰岛素不足的发展有关。
