Kosovskiĭ M I, Turakulov Ia Kh, Mirakhmedov M M, Katkova S P
Probl Endokrinol (Mosk). 1986 May-Jun;32(3):51-4.
Chronic contamination of rats with heliotrin causing the development of hepatitis or hepatocirrhosis and partial hepatectomy to decrease the amount of liver cellular elements resulted in intolerance to glucose, a decrease in the sensitivity of the body to insulin, hyperinsulinemia after a glucose-tolerance test. The content of glycogen in the liver of the heliotrin contaminated rats was much lower than that in the controls and after glucose-tolerance an absolute increment of glycogen in the controls was 8.8-fold higher than in the heliotrin-contaminated rats. It was concluded that a decrease in glucose-tolerance and hyperinsulinemia in patients with chronic hepatitis and hepatocirrhosis were determined by a decrease in the amount of functionally active liver cellular elements and the development of insulin resistance.
用天芥菜精长期污染大鼠，导致肝炎或肝硬化的发生，再进行部分肝切除术以减少肝细胞成分的数量，结果导致大鼠出现葡萄糖不耐受、机体对胰岛素的敏感性降低、葡萄糖耐量试验后出现高胰岛素血症。被天芥菜精污染的大鼠肝脏中糖原含量远低于对照组，且葡萄糖耐量试验后，对照组糖原的绝对增加量比被天芥菜精污染的大鼠高8.8倍。得出的结论是，慢性肝炎和肝硬化患者的葡萄糖耐量降低和高胰岛素血症是由功能性活跃肝细胞成分数量的减少以及胰岛素抵抗的发展所决定的。
