[促黄体素释放激素类似物舒法尔贡在卵泡性卵巢囊肿中的实验应用]
[The experimental use of surfagon, a synthetic analog of luliberin, in follicular ovarian cysts].
作者信息
Krivosheev O G, Chernykh V Ia, Vinogradov V A, Nabatchikova N A, Siutkin E A
出版信息
Probl Endokrinol (Mosk). 1989 Nov-Dec;35(6):54-8.
PMID:2695918
Abstract
The use of a synthetic peptide analog of LH-RH agonist--[D-Ala6, des Gly10, Pro9]-LH-RH ethylamide (surfagon) at microdoses and in short courses returned to normal the ovulatory cycle in the anovulatory condition in rats and caused luteinization of follicular cysts in rats and cows with further normalization of ovarian function. It is assumed that surfagon will be effective for the treatment of anovulatory condition and ovarian follicular cysts in women.
摘要
使用促黄体生成素释放激素（LH-RH）激动剂的合成肽类似物——[D-丙氨酸6，去甘氨酸10，脯氨酸9]-LH-RH乙酰胺（舒法戈）进行微剂量和短期给药，可使无排卵状态大鼠的排卵周期恢复正常，并使大鼠和奶牛的卵泡囊肿黄体化，进而使卵巢功能进一步恢复正常。据推测，舒法戈对治疗女性无排卵状态和卵巢卵泡囊肿将有效。
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