Krivosheev O G, Nabatchikova N A, Pozdniakova G I, Siutkin E A, Vinogradov V A
Probl Endokrinol (Mosk). 1988 Nov-Dec;34(6):62-6.
The biological activity of surfagon (D-Ala6-desGly10-Pro9-ethylamide), a synthetic LH-RH agonist, is dozens of times higher than that of LH-RH in the test of rat hypophyseal stimulation of gonadotropin secretion in vivo and in vitro and in the ovulation induction test. A dose of surfagon required for the stimulation of LH secretion was considerably lower than that for the stimulation of FSH secretion. It may permit the use of surfagon in clinical practice for selective stimulation of secretion either of LH or total gonadotropins--LH and FSH.
促性腺激素释放激素类似物（D-丙氨酸6-去甘氨酸10-脯氨酸9-乙酰胺）在体内外大鼠垂体刺激促性腺激素分泌试验及排卵诱导试验中，其生物活性比促性腺激素释放激素高几十倍。刺激促黄体生成素（LH）分泌所需的促性腺激素释放激素类似物剂量明显低于刺激促卵泡生成素（FSH）分泌所需的剂量。这可能使得促性腺激素释放激素类似物在临床实践中可用于选择性刺激LH或总促性腺激素（LH和FSH）的分泌。
