Early T S, Posner M I, Reiman E M, Raichle M E
McDonnell Center for Studies of Higher Brain Function, Washington University School of Medicine, St. Louis, Missouri 63110.
Psychiatr Dev. 1989 Summer;7(2):109-21.
Our previous paper summarized abundant evidence that schizophrenic patients show forms of sensory and motor hemineglect compatible with a left striato-pallidal hyperactivity model of schizophrenia. In this paper we discuss how the model may also account for some of the cognitive and phenomenological aspects of this disorder. Hemineglect can be associated with pallidal hyperactivity through its mediation of the anterior attention system of the frontal lobe. We postulate that this same attentional deficit can also affect higher functions such as the control of language and thought by internal motivations. Many symptoms of schizophrenia can be explained as a form of hemineglect of these higher functions.
我们之前的论文总结了大量证据，表明精神分裂症患者表现出与精神分裂症的左侧纹状体 - 苍白球活动亢进模型相符的感觉和运动偏侧忽视形式。在本文中，我们将讨论该模型如何也能解释这种疾病的一些认知和现象学方面的问题。偏侧忽视可通过其对额叶前部注意力系统的介导作用与苍白球活动亢进相关联。我们推测，这种相同的注意力缺陷也会影响诸如由内在动机控制语言和思维等高级功能。精神分裂症的许多症状可以被解释为这些高级功能的一种偏侧忽视形式。
