Early T S, Posner M I, Reiman E M, Raichle M E
McDonnell Center for Studies of Higher Brain Function, Washington University School of Medicine, St. Louis, Missouri 63110.
Psychiatr Dev. 1989 Summer;7(2):85-108.
We have observed increased relative blood flow to the left globus pallidus and evidence for subtle forms of right-sided hemineglect in neuroleptic-naive schizophrenic patients. These findings occur in animals following certain lesions such as unilateral destruction of midbrain dopaminergic neurons, and are presumed to be due to left striato-pallidal hyperactivity. A survey of the literature reveals many similarities between animals with unilateral dopaminergic denervation and schizophrenic patients. It has previously been suggested that available evidence does not preclude the possibility that schizophrenic patients have something like a dopaminergic deficiency. Other studies demonstrate that neuroleptics reverse asymmetries in indices of dopamine turnover. A model based upon dopaminergic hemideficiency is outlined, and can potentially explain other abnormalities in schizophrenic patients including eye movement abnormalities and the link between temporal lobe epilepsy and psychosis. A companion article describes how this model can account for some of the phenomenological symptoms of psychosis.
我们观察到，在未服用过抗精神病药物的精神分裂症患者中，左侧苍白球的相对血流量增加，并且存在轻微形式的右侧半侧空间忽视的证据。这些发现在动物身上也会出现，比如在中脑多巴胺能神经元单侧破坏等特定损伤之后，据推测这是由于左侧纹状体 - 苍白球活动亢进所致。对文献的调查揭示了单侧多巴胺能去神经支配的动物与精神分裂症患者之间存在许多相似之处。此前有人提出，现有证据并不排除精神分裂症患者存在类似多巴胺能缺乏的可能性。其他研究表明，抗精神病药物可逆转多巴胺代谢指标的不对称性。本文概述了一种基于多巴胺能半缺乏的模型，该模型有可能解释精神分裂症患者的其他异常情况，包括眼球运动异常以及颞叶癫痫与精神病之间的联系。另一篇配套文章描述了该模型如何解释精神病的一些现象学症状。
