Mellon C D
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City 84132.
Psychiatr Dev. 1989 Summer;7(2):143-58.
For the past 20 years, researchers have been using genetic linkage studies as a tool to better understand the etiology of bipolar disorder. During this time, there have been reports of linkage between the symptom complex of bipolar disorder and 7 genetic markers located on 4 different chromosomal areas. All of these reports continue to be surrounded by controversy causing some observers to consider the field to be ambiguous and contradictory. This review provides some historical perspective on the controversies, while outlining the current status and future direction of the field.
在过去20年里，研究人员一直将基因连锁研究作为一种工具，以更好地理解双相情感障碍的病因。在此期间，有报告称双相情感障碍的症状复合体与位于4个不同染色体区域的7个基因标记之间存在连锁关系。所有这些报告仍存在争议，导致一些观察家认为该领域模糊且矛盾。本综述在概述该领域的现状和未来方向的同时，对这些争议提供了一些历史视角。
