Zapico Augusto G, Fuentes Darío, Rojo-Tirado Miguel A, Calderón Francisco J, Rosenzweig Erika B, Garofano Robert P
Technical University of Madrid, Madrid, Spain (Drs Zapico and Calderón and Messrs Fuentes and Rojo-Tirado); Complutense University of Madrid, Madrid, Spain (Dr Zapico); and New York Presbyterian Hospital/Columbia University Medical Center, New York (Mr Fuentes and Drs Rosenzweig and Garofano).
J Cardiopulm Rehabil Prev. 2016 May-Jun;36(3):203-8. doi: 10.1097/HCR.0000000000000174.
To determine whether the 6-minute walk test (6MWT) is a predictor of peak oxygen uptake ((Equation is included in full-text article.)O2) in patients with idiopathic pulmonary arterial hypertension (IPAH).
A total of 157 patients treated for IPAH completed a 6MWT in accordance with American Thoracic Society standards. Heart rate, pulse oximetry, and Borg rating of perceived exertion were determined at baseline and posttest. A cardiopulmonary exercise test (CPET) was performed on a cycle ergometer using a ramp protocol. Participants were stratified post hoc by age into 3 groups: children (n = 26), adolescents (n = 49), and adults (n = 82). Multiple linear regression analysis was performed to predict peak (Equation is included in full-text article.)O2 from the 6MWT.
The regression equation generated for the children was the only model to strongly predict peak (Equation is included in full-text article.)O2 (r = 0.87; P < .001). Similar models for adolescent (r = 0.59; P < .001) and adult groups (r = 0.68; P < .001) did not achieve the same level of correlation.
Six-Minute Walk Test was able to accurately predict peak (Equation is included in full-text article.)O2 in children (6-12 years) with IPAH; however, the model was weaker for predicting peak (Equation is included in full-text article.)O2 in older populations. These findings suggest that 6MWT may be as valid a test for predicting peak (Equation is included in full-text article.)O2 in children with IPAH as CPET measured peak (Equation is included in full-text article.)O2. In older IPAH populations, CPET is the only reliable method for the evaluation of peak (Equation is included in full-text article.)O2.
确定6分钟步行试验（6MWT）是否可作为特发性肺动脉高压（IPAH）患者峰值摄氧量（（完整文本文章中包含公式）O2）的预测指标。
总共157例接受IPAH治疗的患者按照美国胸科学会标准完成了6MWT。在基线和测试后测定心率、脉搏血氧饱和度和博格主观用力程度评分。使用斜坡方案在功率自行车上进行心肺运动试验（CPET）。事后根据年龄将参与者分为3组：儿童（n = 26）、青少年（n = 49）和成人（n = 82）。进行多元线性回归分析以从6MWT预测峰值（完整文本文章中包含公式）O2。
为儿童生成的回归方程是唯一能强烈预测峰值（完整文本文章中包含公式）O2的模型（r = 0.87；P <.001）。青少年组（r = 0.59；P <.001）和成人组（r = 0.68；P <.001）的类似模型未达到相同的相关性水平。
6分钟步行试验能够准确预测IPAH儿童（6至12岁）的峰值（完整文本文章中包含公式）O2；然而，该模型在预测老年人群的峰值（完整文本文章中包含公式）O2方面较弱。这些发现表明，6MWT对于预测IPAH儿童的峰值（完整文本文章中包含公式）O2可能与CPET测量的峰值（完整文本文章中包含公式）O2一样有效。在老年IPAH人群中，CPET是评估峰值（完整文本文章中包含公式）O2的唯一可靠方法。
