Płaczek Marcin, Kosela Magdalena
Acta Pharm. 2016 Mar;66(1):1-22. doi: 10.1515/acph-2016-0003.
Microscopy belongs to the group of tests, used in pharmaceutical technology, that despite the lapse of time and the development of new analytical methods, still remain irreplaceable for the characterization of dispersed drug dosage forms (e.g., suspensions and emulsions). To obtain complete description of a specific drug formulation, such as parenteral colloidal products, a combination of different microscopic techniques is sometimes required. Electron microscopy methods are the most useful ones; however, even such basic methods as optical microscopy may be helpful for determination of some properties of a sample. The publication explicates the most popular microscopical techniques used nowadays for characterization of the morphology of nanoparticles suspended in pharmaceutical formulations; advantages and disadvantages of these methods are also discussed. Parenteral submicron formulations containing lecithin or a particular phospholipid were chosen as examples.
显微镜检查属于制药技术中使用的一组测试方法，尽管随着时间的推移和新分析方法的发展，对于表征分散药物剂型（如混悬剂和乳剂）而言，它仍然是不可替代的。为了全面描述特定的药物制剂，如肠胃外胶体产品，有时需要结合不同的显微镜技术。电子显微镜方法是最有用的；然而，即使是光学显微镜这样的基本方法，对于确定样品的某些性质也可能有所帮助。该出版物阐述了目前用于表征药物制剂中悬浮纳米颗粒形态的最常用显微镜技术；还讨论了这些方法的优缺点。以含有卵磷脂或特定磷脂的肠胃外亚微米制剂为例。
