Mir-221/222是创新型抗癌疗法的有前景的靶点。
Mir-221/222 are promising targets for innovative anticancer therapy.
作者信息
Di Martino Maria Teresa, Rossi Marco, Caracciolo Daniele, Gullà Annamaria, Tagliaferri Pierosandro, Tassone Pierfrancesco
机构信息
a Department of Experimental and Clinical Medicine , Magna Graecia University, Salvatore Venuta University Campus , Catanzaro , Italy.
b Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology , Temple University , Philadelphia , PA , USA.
出版信息
Expert Opin Ther Targets. 2016 Sep;20(9):1099-108. doi: 10.1517/14728222.2016.1164693. Epub 2016 Mar 21.
INTRODUCTION
MicroRNAs (miRNAs) are key non-coding RNA post-transcriptional regulators of messenger RNAs (mRNAs), and are deeply dysregulated in human cancer. A rising body of evidence indicates that miRNAs represent valuable therapeutic targets. In this light, the cluster miR-221/222 are of particular relevance, given that they are strongly upregulated in a variety of solid and hematologic malignancies.
AREA COVERED
This review summarizes recent findings on the roles played by miR-221/222 in human cancer and their potential clinical value as promising targets for therapeutic studies.
EXPERT OPINION
The rising body of advanced preclinical evidence on the biological significance of miR-221/222 in a variety of malignancies indicates that they will play a crucial role in the future of innovative therapeutic strategies, both as validated biomarkers and targets.
引言
微小RNA（miRNA）是信使核糖核酸（mRNA）关键的非编码RNA转录后调节因子，在人类癌症中存在严重失调。越来越多的证据表明，miRNA是有价值的治疗靶点。鉴于miR-221/222簇在多种实体瘤和血液系统恶性肿瘤中强烈上调，它们具有特别重要的意义。
涵盖领域
本综述总结了miR-221/222在人类癌症中所起作用的最新研究结果及其作为治疗研究有前景靶点的潜在临床价值。
专家观点
关于miR-221/222在多种恶性肿瘤中的生物学意义，越来越多的高级临床前证据表明，它们作为经过验证的生物标志物和靶点，将在创新治疗策略的未来发挥关键作用。
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