Moles Ramona
Department of Pathology and Laboratory Medicine, Center for Viral Oncology, University of Kansas Medical Center, Kansas City, KS, 66160. United States.
Microrna. 2017 Aug 16;6(2):102-109. doi: 10.2174/2211536606666170710183039.
MicroRNAs are short non-coding RNAs involved in critical biological processes. In the past decade, the deregulation of miRNAs has been well-documented in a wide range of human diseases, including cancer. Overexpression and downregulation of miRNAs affect cellular pathways that contribute to carcinogenesis and tumor progression. This evidence makes miRNAs a suitable candidate for therapeutic applications and leads to developing strategies to manipulate their expression. Consistently, in vitro and in vivo studies show that Let-7, miR-10b, miR-21, miR-34, miR-155 and miR-221 are promising targets to develop miRNAs-based therapy for human malignancies. The purpose of this review is to discuss the different approaches that can be used to restore or reduce miRNAs expression in human cancer and the therapeutic implications.
微小RNA是参与关键生物学过程的短链非编码RNA。在过去十年中，微小RNA的失调在包括癌症在内的多种人类疾病中已有充分记录。微小RNA的过表达和下调会影响促成致癌作用和肿瘤进展的细胞途径。这一证据使微小RNA成为治疗应用的合适候选者，并促使人们开发操纵其表达的策略。同样，体外和体内研究表明，Let-7、miR-10b、miR-21、miR-34、miR-155和miR-221是开发基于微小RNA的人类恶性肿瘤治疗方法的有前景的靶点。本综述的目的是讨论可用于恢复或降低人类癌症中微小RNA表达的不同方法及其治疗意义。
