Sanz del Forcallo F J, García Delgado R, Ortiz Maslloréns F
Rev Clin Esp. 1989 Dec;185(9):443-7.
Antibodies to antigens codified by the env and gag genes of HIV were separately assayed for in the sera of 150 infected people. From a practical standpoint, enzyme immunoassay was a more convenient and reliable technique than Western blot. Anti-env was positive in 100% and anti-gag in 70% of the cases. A positive anti-env test was confirmatory of serological diagnosis, but lacked any prognostic value. A higher frequency of negative results for anti-gag antibody was significantly associated with the presence of more severe clinical manifestations, more profound impairment of lymphocyte subpopulations (especially CD4 cells), and the finding of HIV antigens in blood. The absence of anti-gag antibodies, which seem to behave as protective, is an unfavorable feature in the clinical and immunological evaluation of patients.
对150名感染者的血清分别检测了针对HIV env和gag基因编码抗原的抗体。从实际角度来看，酶免疫测定法是一种比蛋白质印迹法更便捷、更可靠的技术。100%的病例抗env呈阳性，70%的病例抗gag呈阳性。抗env检测呈阳性可确诊血清学诊断，但缺乏任何预后价值。抗gag抗体阴性结果的较高频率与更严重的临床表现、淋巴细胞亚群（尤其是CD4细胞）更严重的损伤以及血液中HIV抗原的发现显著相关。抗gag抗体似乎具有保护作用，其缺失在患者的临床和免疫学评估中是一个不利特征。
