Miralles F S, Cárceles M D, Micol J A, Hernández J, del Pino A
Rev Esp Anestesiol Reanim. 1989 Nov-Dec;36(6):315-21.
A randomized, double-blind, prospective study was carried out in 100 patients who had undergone some type of surgical treatment in order to evaluate the degree of pain and relief of pain, the degree of achieved analgesia according to the opinion of the observer and consumption of analgesic agents. The evaluation was carried out on seven occasions during the first 12 hours of the postoperative period. Patients received dexamethasone (4 mg before or after the operation or 8 mg after the operation), 6-methylprednisolone (16 mg at the end of the operation) or nothing (control group). Regardless of type, dose or timing of administration of the drugs, all patients receiving corticosteroids presented less pain, more relief of pain (expressed by themselves or in opinion of the observer) and needed lower doses of analgesics during the studied time.
对100例接受了某种手术治疗的患者进行了一项随机、双盲、前瞻性研究,以评估疼痛程度和疼痛缓解情况、根据观察者意见的镇痛程度以及镇痛药的消耗量。在术后的前12小时内分7次进行评估。患者接受地塞米松(术前或术后4mg或术后8mg)、6-甲基泼尼松龙(手术结束时16mg)或不接受任何治疗(对照组)。无论药物的类型、剂量或给药时间如何,所有接受皮质类固醇治疗的患者在研究期间疼痛较轻、疼痛缓解更明显(由患者自身表述或观察者认为),且所需镇痛药剂量更低。