Mida M, Verhoest P, Boulanger J C, Vitse M
Service de Gynécologie-Obstétrique, CHU, Amiens.
Rev Fr Gynecol Obstet. 1989 Dec;84(12):901-4.
In case of maternal hypothyroidism, the number of miscarriages is higher and reaches 50% in this multicenter study. Several hypotheses are advocated in order to explain this frequent occurrence: the most remarkable is that as substitute treatment is very effective and decreases noticeably the risk of abortion. In case of maternal hypothyroidism, the frequency of abortions in this study reaches 35% before the disease is diagnosed and this figure is not modified (35%) after the diagnosis is made and the treatment initiated. Finally, in case of goiter or euthyroid nodules, there is also a relatively high number of spontaneous abortions. Therefore, there are still a number of unknown factors regarding the role of dysthyroidisms in spontaneous first-trimester abortions.
在孕妇甲状腺功能减退的情况下，流产的发生率更高，在这项多中心研究中达到了50%。为了解释这种频繁发生的情况，人们提出了几种假设：最值得注意的是，替代治疗非常有效，能显著降低流产风险。在孕妇甲状腺功能减退的情况下，本研究中流产发生率在疾病诊断前达到35%，在诊断并开始治疗后这一数字并未改变（35%）。最后，在甲状腺肿或甲状腺功能正常的结节的情况下，自然流产的数量也相对较高。因此，关于甲状腺功能异常在孕早期自然流产中的作用，仍有许多未知因素。
