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床边新生儿重症监护病房先天性膈疝修补术:能否无保留地进行修补?

Bedside Neonatal Intensive Care Unit Correction of Congenital Diaphragmatic Hernia: Is Repair without Compromise?

作者信息

Altokhais Tariq, Soomro Mohammad Aqil, Gado Abdulmonem, Albassam Abdulrahman

机构信息

Department of Surgery, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.

出版信息

Am J Perinatol. 2016 Jul;33(9):861-5. doi: 10.1055/s-0036-1579649. Epub 2016 Mar 9.

DOI:10.1055/s-0036-1579649
PMID:26960699
Abstract

Objectives This study aims to evaluate the feasibility, safety, limitations, and outcomes of performing different surgical approaches and techniques for the bedside repair of congenital diaphragmatic hernia (CDH) in critically ill patients who cannot be transferred to the operating room. Study Design Between December 1997 and July 2013, medical charts of all neonates operated on at the bedside for CDH while on high-frequency oscillatory ventilation (HFOV) and nitric oxide were reviewed. Demographic data; contributing antenatal, perinatal, and postnatal factors; clinical presentation; associated anomalies; respiratory and hemodynamic status; operative details; complications, and outcome were analyzed. Results A total of 101 cases of CDH were operated on, of which 11 were in very critical condition and operated on at the bedside in the neonatal intensive care unit (NICU). The mean gestational age was 38.09 weeks, birth weight, 2.91 kg, and age at surgery, 10 days. All were on HFOV and inotropic support and had pulmonary hypertension. Nine of them were on nitric oxide. Mean preoperative parameters were as follows: O2, 52%; mean airway pressure, 15; pH, 7.40; Po 2, 88.5 mm Hg; and Pco 2, 47 mm Hg. Nine patients underwent laparotomy and two underwent thoracoscopy. All procedures were completed uneventfully. Conclusions Bedside repair of CDH in the NICU while on HFOV is feasible and safe. It is not associated with any compromise in the surgical approach or technique.

摘要

目的 本研究旨在评估对无法转运至手术室的危重症患者采用不同手术入路和技术进行先天性膈疝(CDH)床旁修复的可行性、安全性、局限性及结果。研究设计 回顾1997年12月至2013年7月期间在高频振荡通气(HFOV)和一氧化氮支持下于床旁接受CDH手术的所有新生儿的病历。分析人口统计学数据;产前、围产期和产后相关因素;临床表现;相关畸形;呼吸和血流动力学状态;手术细节;并发症及结果。结果 共对101例CDH患者进行了手术,其中11例病情极其危重,在新生儿重症监护病房(NICU)床旁接受了手术。平均胎龄为38.09周,出生体重2.91 kg,手术时年龄为10天。所有患者均接受HFOV和血管活性药物支持,并患有肺动脉高压。其中9例使用一氧化氮。术前平均参数如下:氧合52%;平均气道压力15;pH值7.40;动脉血氧分压88.5 mmHg;二氧化碳分压47 mmHg。9例患者接受剖腹手术,2例接受胸腔镜手术。所有手术均顺利完成。结论 在NICU中于HFOV支持下进行CDH床旁修复是可行且安全的。这与手术入路或技术上的任何妥协无关。

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