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胎儿咨询对产前先天性手术异常结局的影响。

Impact of fetal counseling on outcome of antenatal congenital surgical anomalies.

作者信息

Sharma Shilpa, Bhanot Ranjana, Deka Dipika, Bajpai Minu, Gupta Devendra K

机构信息

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.

Department of Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Pediatr Surg Int. 2017 Feb;33(2):203-212. doi: 10.1007/s00383-016-4015-x. Epub 2016 Nov 18.

Abstract

AIM

To analyze the impact of counseling on antenatal congenital surgical anomalies (ACSA).

METHODS

Cases presenting with ACSA for fetal counseling and those presenting in post-natal period following diagnosis of ACSA (PACSA) for surgical opinion were analyzed for spectrum, presentation and outcome.

RESULTS

117 cases including ACSA(68);PACSA(49) were analyzed. Gestational age at diagnosis of ACSA;PACSA was 17-37;17-39 weeks (median 24;32 weeks). Diagnoses in ACSA;PACSA included urological (26;31), neurological (10;5), congenital diaphragmatic hernia (CDH)(5;1), gastrointestinal (5;5), lung and chest anomalies (5;1), intraabdominal cysts (4;1), abdominal wall defects (4;0), tumors (3;3), limb anomaly (1;1), esophageal atresia (1;1), conjoint twins (1;0), hepatomegaly (1;0), and major cardiac anomalies (2;0). Two antenatal interventions were done for ACSA; vesicoamniotic shunt and amnioinfusion for oligohydramnios. 17;24 ACSA;PACSA required early surgical intervention in post-natal period. Nine ACSA underwent medical termination of pregnancy and 4 had intrauterine demise. Nine ACSA babies died including two CDH, one gastroschisis, one duodenal atresia, one conjoint twins, one megacystitis with motility disorder and three posterior urethral valves. All PACSA babies survived.

CONCLUSION

Fetal counseling for CSA portrays true outcome of ACSA with 32.3% (22/68) mortality versus 0% for PACSA due to selection bias. However, fetal counseling ensures optimal perinatal care.

摘要

目的

分析咨询对产前先天性外科畸形(ACSA)的影响。

方法

对因胎儿咨询前来就诊的ACSA病例以及在诊断为ACSA后出生前来寻求手术意见的病例(产后先天性外科畸形,PACSA)进行分析,以了解其谱系、表现和结局。

结果

分析了117例病例,包括ACSA(68例)和PACSA(49例)。ACSA和PACSA诊断时的孕周分别为17 - 37周和17 - 39周(中位数分别为24周和32周)。ACSA和PACSA的诊断包括泌尿系统(26例;31例)、神经系统(10例;5例)、先天性膈疝(CDH)(5例;1例)、胃肠道(5例;5例)、肺和胸部畸形(5例;1例)、腹腔内囊肿(4例;1例)、腹壁缺损(4例;0例)、肿瘤(3例;3例)、肢体畸形(1例;1例)、食管闭锁(1例;1例)、联体双胎(1例;0例)、肝肿大(1例;0例)和主要心脏畸形(2例;0例)。对ACSA进行了两项产前干预;膀胱羊膜分流术和羊水过少时的羊膜腔灌注。17例ACSA和24例PACSA在出生后需要早期手术干预。9例ACSA进行了人工流产,4例发生宫内死亡。9例ACSA婴儿死亡,包括2例CDH、1例腹裂、1例十二指肠闭锁、1例联体双胎、1例伴有动力障碍的巨大膀胱和3例后尿道瓣膜。所有PACSA婴儿均存活。

结论

由于选择偏倚,对先天性外科畸形(CSA)进行胎儿咨询显示ACSA的真实死亡率为32.3%(22/68),而PACSA为0%。然而,胎儿咨询可确保最佳的围产期护理。

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