Acta Neuropsychiatr. 1995 Sep;7(3):84-94. doi: 10.1017/S092427080003739X.
Risperidone (Risperdal®) is a recently developed antipsychotic drug with the combination of serotonin-5HT2A-and dopamine-D2-antagonism (SDA). In patients with schizophrenia, risperidone reduces positive symptoms at least equally effective as haloperidol, however, risperidone has a reduced propensity for the induction of extrapyramidal symptoms. In addition, available evidence indicates that risperidone may be an effective treatment for negative symptoms. The optimum daily dose range is between 4 and 8 mgfor most patients. In this review article, risperidone is compared with some other (classical and atypical) neuroleptics. In addition, the pharmacological and pharmacokinetic properties of risperidone are reviewed.
利培酮（利培酮®）是一种最近开发的具有 5-羟色胺 5HT2A-和多巴胺 D2-拮抗作用（SDA）的抗精神病药物。在精神分裂症患者中，利培酮至少与氟哌啶醇同样有效地减少阳性症状，但利培酮降低了诱发锥体外系症状的倾向。此外，现有证据表明，利培酮可能是治疗阴性症状的有效方法。大多数患者的最佳每日剂量范围为 4 至 8 毫克。在这篇综述文章中，将利培酮与其他一些（经典和非典型）神经阻滞剂进行了比较。此外，还回顾了利培酮的药理学和药代动力学特性。
