创伤后应激障碍中预期性关联性负变增加。
Increased anticipatory contingent negative variation in posttraumatic stress disorder.
作者信息
Duan Hongxia, Wang Li, Fernández Guillén, Zhang Kan, Wu Jianhui
机构信息
Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Donders Institute for Brain, Cognition and Behavior, Department for Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, The Netherlands.
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
出版信息
Biol Psychol. 2016 May;117:80-88. doi: 10.1016/j.biopsycho.2016.03.004. Epub 2016 Mar 7.
Altered anticipation processes are implicated across various clinical samples, but few studies focused on the posttraumatic stress disorder (PTSD). We measured contingent negative variation (CNV) in a choice reaction paradigm among 58 survivors of the Wenchuan earthquake, including 28 individuals who were diagnosed with PTSD and 30 without PTSD. Compared to the non-PTSD group, the PTSD group had significantly larger CNV amplitude. On the behavioral level, although the reaction times were comparable between groups, the PTSD group committed more errors than the non-PTSD group. Furthermore, the total PTSD symptom severity score as well as the re-experiencing symptom score were positively related to CNV amplitude. These results suggested that individuals with PTSD might be more alerted to and anticipate more to upcoming events in their environment, yet still have degraded performance in response to the stimulus.
改变的预期过程在各种临床样本中都有涉及，但很少有研究关注创伤后应激障碍（PTSD）。我们在一个选择反应范式中测量了58名汶川地震幸存者的关联性负变（CNV），其中包括28名被诊断为PTSD的个体和30名没有PTSD的个体。与非PTSD组相比，PTSD组的CNV波幅显著更大。在行为层面，尽管两组之间的反应时间相当，但PTSD组比非PTSD组犯的错误更多。此外，PTSD症状严重程度总分以及重新体验症状得分与CNV波幅呈正相关。这些结果表明，患有PTSD的个体可能对其环境中即将发生的事件更加警觉并预期更多，但在对刺激的反应中表现仍然较差。
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