Kimble Matthew, Ruddy Kathryn, Deldin Patricia, Kaufman Milissa
School of Psychology, University of Wales, Bangor, United Kingdom.
J Neuropsychiatry Clin Neurosci. 2004 Winter;16(1):102-8. doi: 10.1176/jnp.16.1.102.
Fourteen veterans with posttraumatic stress disorder (PTSD) and 14 without PTSD participated in a contingent negative variation (CNV)-distraction paradigm. Subjects were instructed to press a button after hearing a high-pitched tone (S2) preceded by a low-pitched tone (S1). One-half of the trials included a white-noise distracter placed in the S1-S2 interval. Posttraumatic stress disorder subjects had larger frontal, but smaller central and parietal CNVs, regardless of condition (distracter, no distracter) or epoch (early CNV, late CNV). In PTSD subjects, the N1/P2 complex was smaller to warning (S1) and distracter stimuli and did not show the extent of facilitation present in non-PTSD subjects. Findings highlight PTSD-related differences in phasic cortical excitability and attention.
14名患有创伤后应激障碍（PTSD）的退伍军人和14名未患PTSD的退伍军人参与了一种关联性负变化（CNV）-分心范式实验。受试者被要求在听到一个低音调（S1）后接着一个高音调（S2）的声音后按下按钮。一半的实验中，在S1-S2间隔中放置了白噪声干扰物。无论处于何种条件（有干扰物、无干扰物）或时段（早期CNV、晚期CNV），创伤后应激障碍受试者的额叶CNV较大，但中央和顶叶CNV较小。在PTSD受试者中，N1/P2复合波对警告（S1）和干扰物刺激的反应较小，并且没有表现出非PTSD受试者中存在的促进程度。研究结果突出了PTSD相关的相位性皮层兴奋性和注意力差异。
