心电图和心脏自主神经指标——急性心肌梗死后女性性别特异性风险分层的意义
Electrocardiographic and Cardiac Autonomic Indices - Implications of Sex-Specific Risk Stratification in Women After Acute Myocardial Infarction.
作者信息
Ubrich Romy, Barthel Petra, Berkefeld Anna, Hnatkova Katerina, Huster Katharina M, Dommasch Michael, Sinnecker Daniel, Steger Alexander, Schmidt Georg, Malik Marek
机构信息
Medizinische Klinik und Poliklinik I, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, München 81675, Germany.
出版信息
Curr Pharm Des. 2016;22(25):3817-28. doi: 10.2174/1381612822666160311115605.
BACKGROUND
The debate on whether sex-specific predictive models improve risk stratification after myocardial infarction is ongoing.
METHODS
This review summarises the current clinical knowledge on sex-specific differences in post-infarction risk stratification parameters. Particular focus is given to electrocardiographic risk factors and indices of cardiac autonomic status.
RESULTS
Differences in the underlying pathophysiology between men and women are known. However, clinical findings often lead to uncertain conclusions for a number of risk predictors including, among others, resting heart rate, heart rate variability, heart rate turbulence, QT interval duration, and QRS-T angle. The review links recent findings in prognostic parameters with successful approaches in sex-specific non-invasive risk stratification.
CONCLUSION
Disparities are described in the current clinical opinions on the relevance of investigated parameters in women and possible directions for further research in the field are given.
背景
关于性别特异性预测模型是否能改善心肌梗死后的风险分层的争论仍在继续。
方法
本综述总结了目前关于心肌梗死后风险分层参数中性别特异性差异的临床知识。特别关注心电图危险因素和心脏自主神经状态指标。
结果
已知男性和女性潜在病理生理学存在差异。然而，对于包括静息心率、心率变异性、心率震荡、QT间期时长和QRS-T夹角等许多风险预测指标，临床研究结果往往得出不确定的结论。本综述将近期预后参数的研究结果与性别特异性非侵入性风险分层的成功方法联系起来。
结论
阐述了目前临床对于所研究参数在女性中的相关性的不同观点，并给出了该领域进一步研究的可能方向。
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