Linde B, Philip A
Department of Clinical Physiology, Huddinge Hospital, Stockholm, Sweden.
Diabetes Res. 1989 Aug;11(4):191-4.
Massage over the site of a subcutaneous insulin injection markedly enhances the absorption of insulin. To investigate whether this reflects an increased dispersion of insulin in the tissue, the area of distribution of radioactivity at 125I-insulin (10 U) injection sites in thigh was determined in eight healthy volunteers by external scanning on a day with standardized massage and on a control day. Insulin absorption (first order disappearance rate constants and appearance of serum immunoreactive insulin, IRI) and plasma glucose were determined concomitantly. The area of distribution of 125I increased 30 +/- 15% (p less than 0.05) on the massage day, which was not significantly different from the change during control (12 +/- 10%). The rate constants for 125I-insulin increased markedly (237 +/- 74%) on the massage day and much less (49 +/- 15%) on the control day (p less than 0.01). Peak IRI levels were 49 +/- 8 mU/l on the massage day and 17 +/- 2 mU/l on the control day (p less than 0.01). The glucose lowering effect was also more pronounced on the massage day. These results indicate that the marked enhancement of insulin absorption induced by massage of the injection site is not directly related to expansion of the insulin depot in the subcutaneous tissue.
在皮下胰岛素注射部位进行按摩可显著增强胰岛素的吸收。为研究这是否反映胰岛素在组织中的分散增加，在八个健康志愿者中，通过外部扫描测定了在标准化按摩日和对照日大腿处注射125I -胰岛素（10 U）部位的放射性分布面积。同时测定胰岛素吸收（一级消失速率常数和血清免疫反应性胰岛素，IRI的出现）和血浆葡萄糖。在按摩日，125I的分布面积增加了30±15%（p<0.05），这与对照期间的变化（12±10%）无显著差异。在按摩日，125I -胰岛素的速率常数显著增加（237±74%），而在对照日增加较少（49±15%）（p<0.01）。在按摩日，IRI峰值水平为49±8 mU/l，在对照日为17±2 mU/l（p<0.01）。在按摩日，降血糖作用也更明显。这些结果表明，注射部位按摩引起的胰岛素吸收显著增强与皮下组织中胰岛素储库的扩大无直接关系。
