Fernqvist-Forbes E, Linde B, Gunnarsson R
Department of Medicine, Huddinge Hospital, Stockholm, Sweden.
J Clin Endocrinol Metab. 1988 Sep;67(3):619-23. doi: 10.1210/jcem-67-3-619.
We studied the effects of insulin-induced hypoglycemia on the absorption of 10 U 125I-labeled soluble human insulin injected sc in the thigh in 10 normal subjects. The disappearance of 125I from the injection site was followed by external gamma-counting. Subcutaneous blood flow (ATBF) was measured concomitantly with the 133Xe washout technique. The plasma glucose nadir [mean, 2.0 +/- 0.1 (+/- SE) mmol/L] occurred at 33 +/- 3 min and resulted in maximal arterial plasma epinephrine concentrations of approximately 6 nmol/L. From 30 min before to 60 min after the glucose nadir the [125I]insulin absorption rate was depressed compared to that during normoglycemia. The first order disappearance rate constants were reduced by approximately 50% (P less than 0.01) during the first 30-min interval after the glucose nadir. During the same period ATBF increased by 100% (P less than 0.05). The results suggest that in normal subjects the absorption of soluble insulin from a sc depot is depressed in connection with hypoglycemia, despite considerably elevated ATBF.
我们研究了胰岛素诱导的低血糖对10名正常受试者大腿皮下注射10 U 125I标记的可溶性人胰岛素吸收的影响。通过外部γ计数追踪125I从注射部位的消失情况。同时采用133Xe洗脱技术测量皮下血流量（ATBF）。血浆葡萄糖最低点[平均值，2.0±0.1（±SE）mmol/L]出现在33±3分钟，导致动脉血浆肾上腺素浓度最高约为6 nmol/L。从葡萄糖最低点前30分钟到最低点后60分钟，与血糖正常期间相比，[125I]胰岛素吸收率降低。在葡萄糖最低点后的第一个30分钟间隔内，一级消失速率常数降低了约50%（P<0.01）。在同一时期，ATBF增加了100%（P<0.05）。结果表明，在正常受试者中，尽管ATBF显著升高，但低血糖时皮下储存库中可溶性胰岛素的吸收仍会受到抑制。
