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粉萆薢总皂苷改善链脲佐菌素诱导的糖尿病肾病。

Total saponin of Dioscoreae hypoglaucae rhizoma ameliorates streptozotocin-induced diabetic nephropathy.

作者信息

Guo Changrun, Ding Gang, Huang Wenzhe, Wang Zhenzhong, Meng Zhaoqing, Xiao Wei

机构信息

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, People's Republic of China.

Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang City, People's Republic of China.

出版信息

Drug Des Devel Ther. 2016 Feb 24;10:799-810. doi: 10.2147/DDDT.S99670. eCollection 2016.

DOI:10.2147/DDDT.S99670
PMID:26966352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4771403/
Abstract

BACKGROUND

Diabetic nephropathy has become the most common cause of morbidity and mortality in diabetic patients. Therefore, there is an urgent need for more effective and safer drugs for use in this condition.

PURPOSE

The aims of this study were to investigate the ameliorative effects of total saponin of Dioscoreae hypoglaucae rhizoma (TSD) on diabetic nephropathy and to explore the potential underlying mechanism(s).

METHODS

Rats with streptozotocin-induced diabetes were orally treated with TSD at 40, 80, and 160 mg/kg/d for 12 weeks. At the end of the treatment, blood, urine, and kidneys were collected for biochemical and histological examination.

RESULTS

The results demonstrated that TSD significantly decreased the fasting blood glucose, glycosylated hemoglobin, urinary protein, serum creatinine, and blood urea nitrogen levels in diabetic rats. The results of histological examinations showed that TSD ameliorated glomerular and tubular pathological changes in diabetic rats. Furthermore, TSD significantly prevented oxidative stress and reduced the renal levels of advanced glycation end products, transforming growth factor-β1, connective tissue growth factor, and tumor necrosis factor-α.

CONCLUSION

This study demonstrated the renoprotective effects of TSD in experimental diabetic nephropathy via a number of different mechanisms.

摘要

背景

糖尿病肾病已成为糖尿病患者发病和死亡的最常见原因。因此，迫切需要更有效、更安全的药物用于治疗这种疾病。

目的

本研究旨在探讨粉背薯蓣总皂苷（TSD）对糖尿病肾病的改善作用，并探索其潜在的作用机制。

方法

用链脲佐菌素诱导糖尿病大鼠，分别给予40、80和160mg/kg/d的TSD灌胃治疗12周。治疗结束时，采集血液、尿液和肾脏进行生化和组织学检查。

结果

结果表明，TSD显著降低了糖尿病大鼠的空腹血糖、糖化血红蛋白、尿蛋白、血清肌酐和血尿素氮水平。组织学检查结果显示，TSD改善了糖尿病大鼠的肾小球和肾小管病理变化。此外，TSD显著预防了氧化应激，并降低了肾脏中晚期糖基化终产物、转化生长因子-β1、结缔组织生长因子和肿瘤坏死因子-α的水平。

结论

本研究通过多种不同机制证明了TSD在实验性糖尿病肾病中的肾脏保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/0fc64c1aa600/dddt-10-799Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/00b36b4b4701/dddt-10-799Fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/828b29a444ef/dddt-10-799Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/0fc64c1aa600/dddt-10-799Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/00b36b4b4701/dddt-10-799Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/3284430a210a/dddt-10-799Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/6af11c6d3daf/dddt-10-799Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/79cbc4a21c8d/dddt-10-799Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/3e31a71725b0/dddt-10-799Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/0ae6c1a85573/dddt-10-799Fig6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a3a/4771403/0fc64c1aa600/dddt-10-799Fig8.jpg

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