College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China.
Institute of Engineering Technology of Chinese Traditional Medicine and Health Food of Hubei Province, Wuhan 430065, China.
Evid Based Complement Alternat Med. 2018 Feb 19;2018:9407945. doi: 10.1155/2018/9407945. eCollection 2018.
Treating type 2 diabetes mellitus (T2DM) using thiazolidinediones and biguanides can present several challenges for patients. Sanggua Drink (SGD) is a commonly used agent in traditional Chinese medicine, and it consists of , , , and . The hypoglycemic effects and mechanisms of SGD extracts on insulin resistance in diabetic rats were investigated. SGD (1.24 g/kg orally) was verified in T2DM rats induced by a high-fat diet and streptozotocin. The results showed that SGD treatment was observed to reduce fasting blood glucose, water and food intake, total cholesterol triglycerides, and LDL, OGTT, FINS, HOMA-IR, GHb, and MDA and increase hepatic glycogen, HDL, SOD, CAT, and GSH-Px in diabetic rats. Simultaneously, SGD treatment by T2DM showed significantly ameliorated pathological changes and reduced inflammation in the pancreas. Treatment was also observed to increase gene and protein expressions of InsR, IRS-2, PI3K, AKT, and Glut4 in the livers of diabetic treated rats. These results suggest that SGD extracts have hypoglycemic properties and may alleviate insulin resistance in T2DM rats through the PI3K/AKT pathway. Therefore, SGD appears to be a promising insulin sensitizer.
用噻唑烷二酮类和双胍类药物治疗 2 型糖尿病 (T2DM) 可能会给患者带来一些挑战。桑果饮 (SGD) 是一种常用的中药制剂，由、、、组成。本研究旨在探讨 SGD 提取物对糖尿病大鼠胰岛素抵抗的降血糖作用及其机制。采用高脂饮食联合链脲佐菌素诱导 T2DM 大鼠，给予 SGD（1.24g/kg 灌胃）进行干预。结果表明，SGD 可降低糖尿病大鼠的空腹血糖、摄水量和摄食量，降低总胆固醇、甘油三酯、LDL，改善 OGTT、FINS、HOMA-IR、GHb 和 MDA，增加肝糖原、HDL、SOD、CAT 和 GSH-Px。同时，SGD 可改善糖尿病大鼠胰腺的病理变化，减轻炎症。此外，SGD 还可增加糖尿病大鼠肝脏中 InsR、IRS-2、PI3K、AKT 和 Glut4 的基因和蛋白表达。这些结果表明，SGD 提取物具有降血糖作用，可能通过 PI3K/AKT 通路缓解 T2DM 大鼠的胰岛素抵抗，因此，SGD 可能是一种有前途的胰岛素增敏剂。
