HLA-DRB1等位基因多态性与肝细胞癌家族聚集性之间的关系
Relationship between HLA-DRB1 allele polymorphisms and familial aggregations of hepatocellular carcinoma.
作者信息
Ma S, Wu J, Wu J, Wei Y, Zhang L, Ning Q, Hu D
机构信息
Department of Infectious Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, P.R.C.
出版信息
Curr Oncol. 2016 Feb;23(1):e1-7. doi: 10.3747/co.23.2839. Epub 2016 Feb 18.
OBJECTIVE
We explored the relationship between HLA-DRB1 allele polymorphisms and familial aggregation of hepatocellular carcinoma (fhcc).
METHODS
Polymerase chain reaction sequence-specific primers were used to determine HLA-DRB1 genotypes for 130 members of families with 2 or more liver cancer patients and for 130 members of families without any diagnosed cancers. The genotype profiles were then compared to explore the relationship between HLA-DRB1 gene polymorphism and fhcc.
RESULT
Of 11 selected alleles, the frequencies of DRB111 and DRB112 were significantly lower in the fhcc group than in no-cancer group (p < 0.05; odds ratio: 0.286; 95% confidence interval: 0.091 to 0.901; and odds ratio: 0.493; 95% confidence interval: 0.292 to 0.893). Differences in the frequencies of the other 9 alleles were not statistically significant in the two groups (p > 0.05).
CONCLUSIONS
Our research suggests that if genetic factors play a role in fhcc, the deficiency in the DRB111 and DRB112 alleles might be the risk factor at work in Guangxi Zhuang Autonomous Region, P.R.C.
目的
我们探讨了人类白细胞抗原-DRB1（HLA-DRB1）等位基因多态性与肝细胞癌家族聚集性（fhcc）之间的关系。
方法
采用聚合酶链反应序列特异性引物，对有2例或更多肝癌患者的家庭中的130名成员以及无任何确诊癌症的家庭中的130名成员进行HLA-DRB1基因型测定。然后比较基因型谱，以探讨HLA-DRB1基因多态性与fhcc之间的关系。
结果
在所选的11个等位基因中，fhcc组中DRB111和DRB112的频率显著低于无癌组（p < 0.05；优势比：0.286；95%置信区间：0.091至0.901；以及优势比：0.493；95%置信区间：0.292至0.893）。其他9个等位基因的频率在两组中差异无统计学意义（p > 0.05）。
结论
我们的研究表明，如果遗传因素在fhcc中起作用，DRB111和DRB112等位基因的缺乏可能是中国广西壮族自治区起作用的危险因素。
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