Holbach L M, Naumann G O, Font R L
Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg, Federal Republic of Germany.
Graefes Arch Clin Exp Ophthalmol. 1989;227(6):584-8. doi: 10.1007/BF02169457.
A 12-month-old boy presented with a diffuse solid tumor of the nasal portions of the lower lid, which had caused almost complete narrowing of the interpalpebral fissure since birth. Clinically, it was suspected to be a mesenchymal tumor. Radiological studies revealed no bony defects in the orbit. The computerized tomographic (CT) scan disclosed a porencephalic cyst in the ipsilateral cerebral hemisphere. Excisional biopsy of the lid tumor revealed ectopic neuroglial tissue. The immunocytochemical demonstration of glial fibrillary acidic protein (GFAP) was consistent with the electron microscopic findings that disclosed fibrillary astrocytes with an abundance of typical 9- to 10-nm glial filaments. Heterotopic neuroglial tissue should be part of the differential diagnosis of congenital lid tumors; its occurrence may be associated with other anomalies of cerebral organogenesis.
一名12个月大的男童出现下睑鼻侧弥漫性实性肿瘤，自出生以来该肿瘤几乎导致睑裂完全狭窄。临床上，怀疑是间充质肿瘤。影像学检查显示眼眶无骨质缺损。计算机断层扫描（CT）显示同侧脑半球有脑穿通畸形囊肿。眼睑肿瘤切除活检显示异位神经胶质组织。胶质纤维酸性蛋白（GFAP）的免疫细胞化学显示与电子显微镜检查结果一致，电子显微镜检查发现有丰富典型的9至10纳米胶质丝的纤维性星形胶质细胞。异位神经胶质组织应作为先天性眼睑肿瘤鉴别诊断的一部分；其发生可能与脑器官发生的其他异常有关。
