Gorenstein A, Kern E B, Facer G W, Laws E R
Arch Otolaryngol. 1980 Sep;106(9):536-40. doi: 10.1001/archotol.1980.00790330016007.
Nasal glioma is a developmental abnormality of neurogenic origin with o malignant potential. An intranasal mass requires careful rhinologic and occassionally ophthalmologic, neurologic, and roentgenologic examinations. With a bony defect, pneumoencephalography, angiography, or computerized tomography may be helpful. In such cases, a neurosurgeon should be available at the time of biopsy. Biopsy is necessary for establishing a histopathologic diagnosis. Aspiration of the tumor with a needle or incisional biopsy may yield inconclusive findings and may be associated with CSF rhinorrhea and meningitis, especially if there is an intracranial connection. With adequate initial removal, excisional biopsy usually offers complete cure. A frontal craniotomy approach is preferred for those patients who have nasal glioma with an intracranial connection, CSF rhinorrhea, or recurrent episodes of meningitis. With no evidence of an intracranial connection, a conservative extracranial approach is recommended.
鼻神经胶质瘤是一种起源于神经源性的发育异常，无恶性潜能。鼻腔内肿物需要仔细的鼻科检查，偶尔还需要眼科、神经科和放射学检查。存在骨缺损时，气脑造影、血管造影或计算机断层扫描可能会有帮助。在这种情况下，活检时应有神经外科医生在场。活检对于确立组织病理学诊断是必要的。用针抽吸肿瘤或切取活检可能得出不确定的结果，并且可能与脑脊液鼻漏和脑膜炎相关，尤其是存在颅内交通时。通过充分的初始切除，切除活检通常可实现完全治愈。对于有颅内交通、脑脊液鼻漏或复发性脑膜炎发作的鼻神经胶质瘤患者，首选额部开颅入路。若没有颅内交通的证据，建议采用保守的颅外入路。
