Teshiba Eri, Miyahara Kohji, Takeya Hiroyuki
a Department of Applied Life Science , Sojo University , Kumamoto , Japan.
Biosci Biotechnol Biochem. 2016 Jul;80(7):1436-9. doi: 10.1080/09168451.2016.1158634. Epub 2016 Mar 11.
High glucose reduced the egg-laying rate of the nematode Caenorhabditis elegans and was dependent on serotonergic signaling. Antidiabetic drugs of the biguanide and thiazolidine classes ameliorated the detrimental effect of glucose on egg-laying rate, suggesting the possibility that this quick and easy assay system may be applicable to whole-animal screening for novel antidiabetic drugs, at least, of these classes.
高糖降低了线虫秀丽隐杆线虫的产卵率，且这一过程依赖于5-羟色胺能信号传导。双胍类和噻唑烷类抗糖尿病药物改善了葡萄糖对产卵率的有害影响，这表明这种快速简便的检测系统至少有可能适用于这些类别的新型抗糖尿病药物的全动物筛选。
