Seiberth V, Linderkamp O
Fortschr Ophthalmol. 1989;86(6):626-30.
A total of 381 surviving prematures (birthweight less than or equal to 2500 g) at the heidelberg University Children's Hospital were examined ophthalmologically between January 1986 and June 1988. Of the 762 eyes, 112 (14.7%) showed acute retinopathy of prematurity (ROP). In our study, a correlation between birthweight, gestational age and retinopathy of prematurity was confirmed. In addition, the results concerning severity, differences between the right and left eye, and the incidence in twins and multiple births were demonstrated. Data were compared with the data in 29 papers dealing with the prevalence of acute ROP since 1968: 12,468 preterm infants were investigated in all papers; 2,087 of these infants (16.7%) showed ROP. In the literature, 8.4% of the premature babies with a birthweight of 1501 to 2500 g were found to have ROP. In our group with the same birthweight, only one baby (birthweight 1510 g) had retinopathy (0.6%). The fact that the average ROP prevalence has not changed significantly indicates that the risk of having retinopathy of prematurity has switched over to the more immature preterms, whose prognosis of survival has improved in the last few years as a result of the improvement in neonatal care.
1986年1月至1988年6月期间，海德堡大学儿童医院对总共381名存活的早产儿（出生体重小于或等于2500克）进行了眼科检查。在762只眼睛中，112只（14.7%）出现了早产儿视网膜病变（ROP）。在我们的研究中，证实了出生体重、胎龄与早产儿视网膜病变之间的相关性。此外，还展示了有关严重程度、左右眼差异以及双胞胎和多胞胎发病率的结果。将这些数据与自1968年以来29篇关于急性ROP患病率的论文中的数据进行了比较：所有论文共调查了12468名早产儿；其中2087名婴儿（16.7%）出现了ROP。在文献中，出生体重为1501至2500克的早产儿中有8.4%被发现患有ROP。在我们相同出生体重组中，只有一名婴儿（出生体重1510克）患有视网膜病变（0.6%）。急性ROP的平均患病率没有显著变化这一事实表明，早产儿视网膜病变的风险已转移到更不成熟的早产儿身上，由于新生儿护理的改善，这些早产儿的存活预后在过去几年有所改善。
