偏头痛的全基因组关联研究：现状与未来方向
Genome-wide association studies in migraine: current state and route to follow.
作者信息
Nyholt Dale R, van den Maagdenberg Arn M J M
机构信息
aStatistical and Genomic Epidemiology Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia bDepartments of Human Genetics and Neurology, Leiden University Medical Center, Leiden, The Netherlands.
出版信息
Curr Opin Neurol. 2016 Jun;29(3):302-8. doi: 10.1097/WCO.0000000000000316.
PURPOSE OF REVIEW
Genome-wide association studies (GWAS) have revealed over a dozen genetic factors robustly associated with the common forms of migraine. The identification of these factors, the implicated biological mechanisms, and whether they are of use in basic research and clinic practice will be discussed.
RECENT FINDINGS
Several GWAS have been performed in recent years. New approaches are being tested to identify how information of genetic susceptibility factors can be used in research and the clinic. Still, we are only at the beginning of understanding how the genetic factors may be involved in migraine pathophysiology.
SUMMARY
The identification of genetic factors that confer risk for the common forms of migraine by GWAS has given insight into the genetic underpinning of migraine pathophysiology. Still, the interpretation of the findings of GWAS is not straightforward. Various strategies are being tested to investigate which pathophysiological mechanisms are involved, how they can be studied, and what this means for clinical diagnosis, and even care.
综述目的
全基因组关联研究（GWAS）已揭示出十多种与常见类型偏头痛密切相关的遗传因素。本文将讨论这些因素的识别、涉及的生物学机制，以及它们在基础研究和临床实践中的用途。
最新发现
近年来已开展了多项GWAS。目前正在测试新方法，以确定如何在研究和临床中利用遗传易感性因素的信息。然而，我们对于遗传因素如何参与偏头痛病理生理学的理解仍处于起步阶段。
总结
通过GWAS识别出的导致常见类型偏头痛风险的遗传因素，为偏头痛病理生理学的遗传基础提供了见解。然而，GWAS结果的解读并非易事。目前正在测试各种策略，以研究涉及哪些病理生理机制、如何对其进行研究，以及这对临床诊断乃至治疗意味着什么。
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