Katona B, Wason S
Department of Pharmacy, Francis Scott Key Medical Center, Baltimore, MD.
J Emerg Med. 1989 Nov-Dec;7(6):627-31. doi: 10.1016/0736-4679(89)90010-3.
Superwarfarins consist of two classes of compounds, the 4-hydroxycoumarins and the indandiones. These compounds have replaced warfarin as an anticoagulant rodenticide. This article is a summary of the clinical effects produced by accidental and deliberate ingestions of superwarfarins. Most accidental ingestions occur in childhood and result in a benign outcome. Deliberate overdoses usually involve repeated ingestions of large quantities of superwarfarins that have resulted in prolonged laboratory evidence of interference with clotting; serious bleeding has been rare. This article suggests an approach to the management of patients with accidental and deliberate anticoagulant rodenticide ingestions.
超级华法林由两类化合物组成，即4-羟基香豆素类和茚满二酮类。这些化合物已取代华法林成为一种抗凝血灭鼠剂。本文是关于意外和故意摄入超级华法林所产生临床效应的综述。大多数意外摄入发生在儿童时期，结果通常为良性。故意过量服用通常涉及反复大量摄入超级华法林，这已导致实验室检查显示凝血干扰持续存在；严重出血情况较为罕见。本文提出了一种针对意外和故意摄入抗凝血灭鼠剂患者的处理方法。
