Jiang Huayong, Xu Weidong, Zhang Fuli, Wei Li, Wang Yajie, Wang Yadi, Liu Chuan
aDepartment of Radiation Oncology, General Hospital of Beijing Military Command, Beijing bDepartment of Oncology, 401 Hospital of PLA, Qingdao cDepartment of Oncology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Melanoma Res. 2016 Jun;26(3):290-9. doi: 10.1097/CMR.0000000000000246.
Accumulating evidence has suggested that the XRCC1 Arg399Gln and Arg194Trp polymorphisms might be related to cutaneous melanoma susceptibility. However, epidemiologic findings have been inconsistent. We have assessed reported studies by meta-analysis to perform a more precise estimation of the association between the XRCC1 two polymorphisms (Arg399Gln, Arg194Trp) and risk of cutaneous melanoma. A total of seven eligible articles were selected for this meta-analysis, including 3454 cases and 3811 controls for the XRCC1 Arg399Gln polymorphism and 1256 cases and 1575 controls for the XRCC1 Arg194Trp polymorphism. Overall, no significant associations were found in all genetic models when the studies were pooled into the meta-analysis for the Arg399Gln and Arg194Trp polymorphisms. When stratified by source of control, significant associations were found for the Arg399Gln polymorphism in the population-based subgroup under AA versus GG [odds ratio (OR)=1.43, 95% confidence interval (CI)=1.08-1.88]; the dominant model AA/GA versus GG (OR=1.25, 95% CI=1.04-1.51); and the recessive model AA versus GA/GG (OR=1.31, 95% CI=1.01-1.68). No significant associations were found for the Arg194Trp polymorphism in the subgroup analysis. This meta-analysis suggested that the XRCC1 Arg399Gln polymorphism was a risk factor for cutaneous melanoma in population-based subgroup.
越来越多的证据表明，XRCC1基因的Arg399Gln和Arg194Trp多态性可能与皮肤黑色素瘤易感性相关。然而，流行病学研究结果并不一致。我们通过荟萃分析评估了已发表的研究，以更精确地估计XRCC1基因的两种多态性（Arg399Gln、Arg194Trp）与皮肤黑色素瘤风险之间的关联。本荟萃分析共纳入7篇符合条件的文章，其中包括3454例病例和3811例对照用于XRCC1基因Arg399Gln多态性分析，以及1256例病例和1575例对照用于XRCC1基因Arg194Trp多态性分析。总体而言，在对Arg399Gln和Arg194Trp多态性进行荟萃分析时，在所有遗传模型中均未发现显著关联。按对照来源分层时，在基于人群的亚组中，对于Arg399Gln多态性，在AA与GG比较时发现显著关联[比值比（OR）=1.43，95%置信区间（CI）=1.08 - 1.88]；显性模型AA/GA与GG比较时（OR=1.25，95%CI=1.04 - 1.51）；隐性模型AA与GA/GG比较时（OR=1.31，95%CI=1.01 - 1.68）。在亚组分析中，未发现Arg194Trp多态性有显著关联。该荟萃分析表明，在基于人群的亚组中，XRCC1基因的Arg399Gln多态性是皮肤黑色素瘤的一个危险因素。
