Spring In ''t Veld Laura G, de Vries Linda S, Alderliesten Thomas, Benders Manon J N L, Groenendaal Floris
Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.
Neonatology. 2016;110(1):27-32. doi: 10.1159/000444121. Epub 2016 Mar 12.
Cranial magnetic resonance imaging (MRI) is associated with neurodevelopmental outcome in full-term infants with neonatal encephalopathy (NE) following presumed perinatal asphyxia. The aim of this study is to relate 2-dimensional measurements of the basal ganglia and thalami (BGT) and cerebellum in the first week after birth and after 3 months with neurodevelopmental outcome at 18 months.
Retrospectively, 29 full-term infants with NE following presumed perinatal asphyxia who had a cranial MRI in the first week after birth were studied serially. One- and 2-dimensional measurements were obtained and related to different patterns of brain injury, and neurodevelopmental outcome at 18 months. A Griffiths developmental quotient <85 or cerebral palsy was considered adverse.
On the first MRI, the adverse outcome group showed increased basal ganglia width (42.1 ± 0.1 vs. 40.3 ± 0.3 mm, p < 0.001), thalamic width (40.3 ± 0.1 vs. 39.3 ± 1.0 mm, p < 0.001), and basal ganglia surface (1,230 ± 21 vs. 1,199 ± 36 mm2, p = 0.007) compared to the favorable outcome group. In the BGT lesions group, basal ganglia width and thalamic width were increased compared to the watershed infarction group (42.1 ± 0.1 vs. 40.9 ± 0.8 mm, p < 0.001, and 40.3 ± 0.1 vs. 39.9 ± 0.5 mm, p = 0.01, respectively). On the second MRI, cerebellar width was larger in the favorable outcome group (p = 0.025). There was a greater increase in dimensions between both MRI time points for basal ganglia width (p = 0.014), basal ganglia surface (p = 0.028) and thalamic width (p = 0.012) in the favorable outcome group.
One- and 2-dimensional measurements for basal ganglia surface, BGT width and cerebellar width are associated with neurodevelopmental outcome at 18 months.
对于假定围产期窒息后患有新生儿脑病（NE）的足月儿，头颅磁共振成像（MRI）与神经发育结局相关。本研究的目的是将出生后第一周及3个月后基底节和丘脑（BGT）以及小脑的二维测量结果与18个月时的神经发育结局联系起来。
回顾性地对29例假定围产期窒息后患有NE且在出生后第一周进行了头颅MRI检查的足月儿进行系列研究。获取一维和二维测量结果，并将其与不同的脑损伤模式以及18个月时的神经发育结局相关联。将格里菲斯发育商<85或患有脑瘫视为不良结局。
在首次MRI检查时，与良好结局组相比，不良结局组的基底节宽度增加（42.1±0.1 vs. 40.3±0.3 mm，p<0.001）、丘脑宽度增加（40.3±0.1 vs. 39.3±1.0 mm，p<0.001）以及基底节表面积增加（1230±21 vs. 1199±36 mm²，p = 0.007）。在BGT病变组中，与分水岭梗死组相比，基底节宽度和丘脑宽度增加（分别为42.1±0.1 vs. 40.9±0.8 mm，p<0.001，以及40.3±0.1 vs. 39.9±0.5 mm，p = 0.01）。在第二次MRI检查时，良好结局组的小脑宽度更大（p = 0.025）。良好结局组在两次MRI检查时间点之间基底节宽度（p = 0.014）、基底节表面积（p = 0.028）和丘脑宽度（p = ）的维度增加更大。
基底节表面积、BGT宽度和小脑宽度的一维和二维测量结果与18个月时的神经发育结局相关。
