Smyth B, Ong S
Department of Nephrology, St George Hospital, Sydney, New South Wales, Australia.
Intern Med J. 2016 Mar;46(3):360-3. doi: 10.1111/imj.13001.
We present the case of a 59-year-old woman with chronic kidney disease who suffered severe hypocalcaemia and hypophosphataemia after receiving denosumab and intravenous iron. This potentially life-threatening adverse drug interaction has never been reported before. We propose a mechanism to explain it with reference to the physiological derangements caused by both agents on calcium and phosphate homeostasis.
我们报告了一例59岁患有慢性肾脏病的女性病例，该患者在接受地诺单抗和静脉注射铁剂后出现了严重的低钙血症和低磷血症。这种潜在的危及生命的药物相互作用此前从未有过报道。我们提出了一种机制，参考这两种药物对钙和磷稳态造成的生理紊乱来解释这一现象。
