Gerle Christoph
Picobiology Institute, Department of Life Science, Graduate School of Life Science, University of Hyogo, Kamigori, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan.
Biochim Biophys Acta. 2016 Aug;1857(8):1191-1196. doi: 10.1016/j.bbabio.2016.03.008. Epub 2016 Mar 9.
The mitochondrial permeability transition is an inner mitochondrial membrane event involving the opening of the permeability transition pore concomitant with a sudden efflux of matrix solutes and breakdown of membrane potential. The mitochondrial F(o)F(1) ATP synthase has been proposed as the molecular identity of the permeability transition pore. The likeliness of potential pore-forming sites in the mitochondrial F(o)F(1) ATP synthase is discussed and a new model, the death finger model, is described. In this model, movement of a p-side density that connects the lipid-plug of the c-ring with the distal membrane bending Fo domain allows reversible opening of the c-ring and structural cross-talk with OSCP and the catalytic (αβ)(3) hexamer. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.
线粒体通透性转换是线粒体内膜发生的一个事件，涉及通透性转换孔的开放，同时伴随着基质溶质的突然外流和膜电位的崩溃。线粒体F(o)F(1) ATP合酶被认为是通透性转换孔的分子实体。本文讨论了线粒体F(o)F(1) ATP合酶中潜在成孔位点的可能性，并描述了一种新模型——死亡手指模型。在该模型中，连接c环脂质塞与远端膜弯曲F0结构域的p侧密度的移动允许c环可逆开放，并与寡霉素敏感性相关蛋白（OSCP）和催化性（αβ）(3)六聚体发生结构相互作用。本文是由保罗·贝尔纳迪教授编辑的特刊“EBEC 2016：第19届欧洲生物能量学会议，2016年7月2 - 6日，意大利里瓦德尔加尔达”的一部分。
