The Pulmonary Center, Boston University School of Medicine, 72 East Concord Street, R-304, Boston, MA 02118, USA.
Am J Respir Crit Care Med. 2010 May 1;181(9):997-1002. doi: 10.1164/rccm.200908-1304OC. Epub 2010 Jan 21.
The impact of REM-predominant sleep-disordered breathing (SDB) on sleepiness, quality of life (QOL), and sleep maintenance is uncertain.
To evaluate the association of SDB during REM sleep with daytime sleepiness, health-related QOL, and difficulty maintaining sleep, in comparison to their association with SDB during non-REM sleep in a community-based cohort.
Cross-sectional analysis of 5,649 Sleep Heart Health Study participants (mean age 62.5 [SD = 10.9], 52.6% women, 22.6% ethnic minorities). SDB during REM and non-REM sleep was quantified using polysomnographically derived apnea-hypopnea index in REM (AHI(REM)) and non-REM (AHI(NREM)) sleep. Sleepiness, sleep maintenance, and QOL were respectively quantified using the Epworth Sleepiness Scale (ESS), the Sleep Heart Health Study Sleep Habit Questionnaire, and the physical and mental composites scales of the Medical Outcomes Study Short Form (SF)-36.
AHI(REM) was not associated with the ESS scores or the physical and mental components scales scores of the SF-36 after adjusting for demographics, body mass index, and AHI(NREM) x AHI(REM) was not associated with frequent difficulty maintaining sleep or early awakening from sleep. AHI(NREM) was associated with the ESS score (beta = 0.25; 95% confidence interval [CI], 0.16 to 0.34) and the physical (beta = -0.12; 95% CI, -0.42 to -0.01) and mental (beta = -0.20; 95% CI, -0.20 to -0.01) components scores of the SF-36 adjusting for demographics, body mass index, and AHI(REM).
In a community-based sample of middle-aged and older adults, REM-predominant SDB is not independently associated with daytime sleepiness, impaired health-related QOL, or self-reported sleep disruption.
快速眼动（REM）睡眠为主的睡眠呼吸紊乱（SDB）对嗜睡、生活质量（QOL）和睡眠维持的影响尚不确定。
在社区为基础的队列中，与非快速眼动（NREM）睡眠相比，评估 REM 睡眠期间 SDB 与日间嗜睡、健康相关 QOL 和睡眠维持困难的相关性。
对睡眠心脏健康研究 5649 名参与者（平均年龄 62.5 [SD=10.9]，52.6%为女性，22.6%为少数民族）进行横断面分析。使用多导睡眠图衍生的 REM 睡眠呼吸暂停低通气指数（AHI（REM））和非 REM 睡眠呼吸暂停低通气指数（AHI（NREM））来量化 REM 和非 REM 睡眠期间的 SDB。使用 Epworth 嗜睡量表（ESS）、睡眠心脏健康研究睡眠习惯问卷和医疗结局研究短表单（SF）-36 的身体和心理综合量表分别量化嗜睡、睡眠维持和 QOL。
在调整人口统计学、体重指数和 AHI（NREM）后，AHI（REM）与 ESS 评分或 SF-36 的身体和心理成分量表评分均无相关性，而 AHI（REM）×AHI（NREM）与频繁睡眠维持困难或早醒无关。AHI（NREM）与 ESS 评分（β=0.25；95%置信区间 [CI]，0.16 至 0.34）以及 SF-36 的身体（β=-0.12；95%CI，-0.42 至-0.01）和心理（β=-0.20；95%CI，-0.20 至-0.01）成分评分相关，调整人口统计学、体重指数和 AHI（REM）。
在一个以中年和老年人为基础的社区样本中，REM 为主的 SDB 与日间嗜睡、健康相关 QOL 受损或自我报告的睡眠中断无关。
