Kono Takeyuki, Saito Koichiro, Yabe Haruna, Uno Kosuke, Ogawa Kaoru
Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
Head Neck. 2016 Jul;38(7):1085-90. doi: 10.1002/hed.24412. Epub 2016 Mar 11.
This study was designed to comparatively assess laryngeal function and quality of life (QOL) of patients after laser surgery (LS) or radiotherapy (RT) for early glottic cancer.
Sixty-four patients with T1 glottic cancer treated with RT or type II cordectomy underwent both subjective and objective vocal assessments. The LS group was divided into the following: (1) vaporization with defocused mode (laser surgery [LS]-Vap); and (2) excision with focused mode using lower power (LS-Ex).
Auditory-perceptual evaluation and videostroboscopic images in the LS-Ex group worsened shortly after treatment and time-dependent recovery was quicker than in the LS-Vap group. The LS-Ex group showed equivalent posttherapeutic vocal function with the RT group by acoustics, aerodynamics, and self-assessment questionnaire analysis, whereas the LS-Vap group showed statistically significant worse function.
The multidimensional assessment showed that early glottic cancer could be successfully treated by either RT or LS-Ex with equivalent posttherapeutic laryngeal function and QOL. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1085-1090, 2016.
本研究旨在比较评估早期声门癌患者接受激光手术（LS）或放射治疗（RT）后的喉功能和生活质量（QOL）。
64例接受RT或II型声带切除术治疗的T1声门癌患者接受了主观和客观的嗓音评估。LS组分为以下两类：（1）散焦模式汽化（激光手术[LS]-Vap）；（2）低功率聚焦模式切除（LS-Ex）。
LS-Ex组治疗后不久听觉感知评估和频闪喉镜图像变差，且随时间的恢复比LS-Vap组更快。通过声学、空气动力学和自我评估问卷分析，LS-Ex组治疗后的嗓音功能与RT组相当，而LS-Vap组的功能在统计学上显著较差。
多维度评估表明，早期声门癌通过RT或LS-Ex均可成功治疗，治疗后的喉功能和QOL相当。©2016威利期刊公司。头颈外科38:1085 - 1090,2016。
