Alkan Uri, Nachalon Yuval, Shkedy Yotam, Yaniv Dan, Shvero Jacob, Popovtzer Aron
Department of Otorhinolaryngology - Head and Neck Surgery, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Department of Radiation Oncology, Davidoff Cancer Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Head Neck. 2017 Jun;39(6):1101-1105. doi: 10.1002/hed.24723. Epub 2017 Mar 28.
The optimal treatment method of T1 glottic squamous cell carcinoma (SCC) with involvement of the anterior commissure is still debatable. We compared the outcomes of radiotherapy (RT) and transoral laser microsurgery (TLM).
Data were retrospectively collected for 54 patients who were treated by RT (n = 38) or TLM (n = 16) from 2006 to 2013.
No between-group differences were found in demographic or risk factors. Recurrence was noted in 6 patients of the TLM group and 5 of the RT group. There was a near-significant association of TLM with recurrence (p = .053). Radiation was associated with a higher 5-year disease-free survival (DFS) (87.3% vs 74.9%; p = .037). Both groups had excellent rates for local control (75% and 97%, respectively), and overall survival (78.9 and 87.5%, respectively). There were no significant differences in outcome parameters by tumor classification.
TLM is associated with higher recurrence rates and lower DFS. Both patients with T1a and T1b disease had the same outcome parameters. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1101-1105, 2017.
前联合受累的T1声门鳞状细胞癌（SCC）的最佳治疗方法仍存在争议。我们比较了放射治疗（RT）和经口激光显微手术（TLM）的治疗效果。
回顾性收集了2006年至2013年期间接受RT（n = 38）或TLM（n = 16）治疗的54例患者的数据。
在人口统计学或风险因素方面未发现组间差异。TLM组有6例患者复发，RT组有5例。TLM与复发之间存在接近显著的关联（p = 0.053）。放射治疗与更高的5年无病生存率（DFS）相关（87.3%对74.9%；p = 0.037）。两组的局部控制率（分别为75%和97%）和总生存率（分别为78.9%和87.5%）都很高。按肿瘤分类，结局参数无显著差异。
TLM与更高的复发率和更低的DFS相关。T1a和T1b疾病患者的结局参数相同。© 2017威利期刊公司。头颈外科39: 1101 - 1105, 2017。
