Butelman E R
Department of Psychology, University College London, UK.
Pharmacol Biochem Behav. 1989 Sep;34(1):13-6. doi: 10.1016/0091-3057(89)90345-6.
N-Methyl-d-aspartate (NMDA) receptors have been implicated with the triggering of long-term potentiation, a currently studied physiological model of learning and memory. The compound (+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine maleate (MK-801) has recently been classified as a potent and selective NMDA antagonist acting at the associated ion channel. After determination of the highest intraperitoneal dose of MK-801 at which increases in activity (measured in photocell activity cages and 3-arm maze) were not observed (0.2 mg/kg), rats that had been previously trained to obtain food pellets in an 8-arm radial maze up to criterion were tested with 0.1 and 0.2 mg/kg doses. Dose-related decreases in "efficiency" in the task were found. The present findings support the suggestion that NMDA antagonists cause impairments in "working memory" and also support the status of long-term potentiation as a physiological model of memory.
N-甲基-D-天冬氨酸（NMDA）受体与长时程增强的触发有关，长时程增强是目前正在研究的一种学习和记忆的生理模型。化合物（+）-5-甲基-10,11-二氢-5H-二苯并[a,d]环庚烯-5,10-亚胺马来酸盐（MK-801）最近被归类为一种强效且选择性的NMDA拮抗剂，作用于相关离子通道。在确定未观察到活动增加（在光电管活动笼和三臂迷宫中测量）的MK-801最高腹腔注射剂量（0.2mg/kg）后，对先前在八臂放射状迷宫中训练至标准以获取食物颗粒的大鼠用0.1mg/kg和0.2mg/kg剂量进行测试。发现任务中的“效率”存在剂量相关的降低。目前的研究结果支持NMDA拮抗剂会导致“工作记忆”受损的观点，也支持长时程增强作为记忆生理模型的地位。
