Ward L, Mason S E, Abraham W C
Department of Psychology, University of Otago, Dunedin, New Zealand.
Pharmacol Biochem Behav. 1990 Apr;35(4):785-90. doi: 10.1016/0091-3057(90)90359-p.
The dose- and time-dependent effects of N-methyl-D-aspartate receptor/channel antagonists on radial 8-arm maze performance were examined in rats. Both CPP (1.0-30 mg/kg), a competitive NMDA antagonist, and MK-801 (0.1-1.0 mg/kg), a noncompetitive NMDA antagonist, produced dose-dependent increases in the number of errors made to sample all 8 baited arms. The effective doses of both drugs produced maximal performance impairments 2 hr after IP injection, and no effects after 24 hr. In a second radial arm maze task where only 4 arms were baited, CPP (10 mg/kg) had a somewhat greater effect on the number of working memory errors than on reference memory errors. MK-801 (0.1, 0.33 mg/kg) had no effects on either this task or on a task involving a 1-hr delay between correct choices 4 and 5 on the 8 choice task. CPP (10 mg/kg), however, impaired performance on this latter task. These results indicate that doses of NMDA antagonists, sufficient to block hippocampal long-term potentiation, also disrupt radial arm maze performance.
研究了N-甲基-D-天冬氨酸受体/通道拮抗剂对大鼠放射状八臂迷宫行为表现的剂量和时间依赖性影响。竞争性NMDA拮抗剂CPP（1.0 - 30毫克/千克）和非竞争性NMDA拮抗剂MK - 801（0.1 - 1.0毫克/千克）均使探索所有8个诱饵臂时的错误数量呈剂量依赖性增加。两种药物的有效剂量在腹腔注射后2小时产生最大行为表现损伤，24小时后无影响。在第二个放射状臂迷宫任务中，仅4个臂设置诱饵，CPP（10毫克/千克）对工作记忆错误数量的影响比对参考记忆错误的影响稍大。MK - 801（0.1、0.33毫克/千克）对该任务或对涉及在8选任务中正确选择4和5之间有1小时延迟的任务均无影响。然而，CPP（10毫克/千克）损害了后一任务的行为表现。这些结果表明，足以阻断海马体长期增强效应的NMDA拮抗剂剂量也会破坏放射状臂迷宫行为表现。
