Morley S L, Hudson C L, Llewelyn C A, Wells A W, Johnson A L, Williamson L M
Cambridge Blood Centre, NHS Blood and Transplant, Cambridge, UK.
Scottish National Blood Transfusion Service, Edinburgh, UK.
Transfus Med. 2016 Apr;26(2):111-7. doi: 10.1111/tme.12283. Epub 2016 Mar 11.
To describe the epidemiology of blood transfusion in children: including the incidence of transfusion, the diagnoses leading to transfusion, donor exposure (DE) and post-transfusion survival.
The Epidemiology and Survival of Transfusion Recipients (EASTR) Study was a multi-centre epidemiological study with prospective survival monitoring. Cross-sectional sampling of adult and paediatric transfusion recipients in 29 hospitals was used to select three separate cohorts of red cell (RBC), platelet (PLT) and fresh frozen plasma (FFP) recipients between October 2001 and September 2002. This paper presents the analysis of results for children <16 years.
Children <16 years comprised 449 (5%) of the RBC, 362 (9%) of the FFP and 452 (13%) of the PLT recipients. In children 54% of RBC, 63% FFP and 45% PLT recipients were under 1 year of age and 57% RBC, 60% FFP and 52% PLT were male. Median (IQR) DEduring the study year was 3(2-8); 5(2-13) and 11(6-21) in the RBC, FFP and PLT cohorts, respectively. A total of 20% of RBC, 31% of FFP and 54% of PLT recipients had been exposed to >10 donors. Perinatal conditions were the commonest indication for transfusion in the RBC (36%) and FFP (44%) cohorts and comprised 31% of the PLT cohort. Medical conditions (48%), predominantly malignancy (33%), were the most frequent indication in the PLT cohort. The 10 year (95% CI) survival rates were 81% (77-85%), 72% (67-76%) and 71% (66-75%)for RBC, FFP and PLT cohorts, respectively.
Around half of paediatric transfusion recipients are under 1 year of age. Exposure to components from multiple donors is common. At least 70% of paediatric recipients are long survivors and are at risk for late complications of transfusion.
描述儿童输血的流行病学情况，包括输血发生率、导致输血的诊断、供血者暴露情况（DE）以及输血后生存率。
输血受者的流行病学与生存情况（EASTR）研究是一项进行前瞻性生存监测的多中心流行病学研究。采用对29家医院的成人及儿童输血受者进行横断面抽样的方法，在2001年10月至2002年9月期间选取了红细胞（RBC）、血小板（PLT）和新鲜冰冻血浆（FFP）受者三个独立队列。本文呈现了对16岁以下儿童的结果分析。
16岁以下儿童占红细胞受者的449例（5%）、新鲜冰冻血浆受者的362例（9%）以及血小板受者的452例（13%）。在儿童中，54%的红细胞受者、63%的新鲜冰冻血浆受者和45%的血小板受者年龄在1岁以下，57%的红细胞受者、60%的新鲜冰冻血浆受者和52%的血小板受者为男性。在研究年度内，红细胞、新鲜冰冻血浆和血小板队列的DE中位数（四分位间距）分别为3（2 - 8）、5（2 - 13）和11（6 - 21）。共有20%的红细胞受者、31%的新鲜冰冻血浆受者和54%的血小板受者接触过10名以上供血者。围产期疾病是红细胞队列（36%）和新鲜冰冻血浆队列（44%）中最常见的输血指征，占血小板队列的31%。疾病状况（48%），主要是恶性肿瘤（33%），是血小板队列中最常见的指征。红细胞、新鲜冰冻血浆和血小板队列的10年（95%CI）生存率分别为81%（77 - 85%）、72%（67 - 76%）和71%（66 - 7?%）。
约一半的儿童输血受者年龄在1岁以下。接触多个供血者的成分很常见。至少70%的儿童受者是长期存活者，存在输血后期并发症的风险。 （注：原文中“71%（66 - 7?%）”这里最后一个数字可能有误，翻译时保留了原文情况）
